Vermeer Lab

Graduate Student Mentor

Primary Research Focus

The Vermeer Lab focuses on defining mechanisms of metastasis and identifying novel targets for therapeutic intervention.

Recent work from the Vermeer lab shows that tumors release small vesicles called exosomes that induce tumor innervation. Patients with densely innervated tumors suffer with increased rates of metastasis.

Now that we have identified a mechanism driving tumor innervation, the Vermeer Lab is currently focused on developing ways to block it. The lab studies many different types of solid tumors to better understand at the molecular level why some tumors are more innervated than others. The goal is to define key signatures that result in densely innervated tumors and develop therapies to block this effect.

The lab’s studies span the breadth of scientific techniques from basic/classical approaches (e.g., molecular biology, protein biochemistry and microscopy) to complex in vivo studies using wild-type as well as transgenic mouse models to, finally, proceed to validation studies using human samples.

The Vermeer lab researches changes in tumor cells by not only analyzing genetic alterations but also determining how these changes affect protein expression, localization and function. Importantly, the lab equally focuses on cells in the tumor microenvironment to define how they contribute to disease initiation and/or progression.

About the Vermeer Lab

Lab Projects and News

Meet the Vermeer Team