Surendran Lab

Graduate Student Mentor

Primary Research Focus

The Surendran Lab studies kidney development and disease by determining the molecular basis by which diverse cell types of the kidney develop and are maintained. The Surendran Lab uses novel genetic mouse models, along with cell and ex vivo organ cultures, to identify genes critical for kidney development and/or maintenance of kidney functions.

The Surendran Lab focuses on two areas:

  1. The molecular mechanisms regulating kidney collecting duct development and maintenance
  2. The cellular and genetic basis of kidney diseases associated with Alagille Syndrome patients.

The lab uses mouse genetic tools for ectopic expression, loss of function and cell lineage tracing studies in specific populations of cells of the developing mouse kidneys to understand the molecular regulators that ensure normal kidney development and maintenance. These studies have provided insights into the potential genetic and cellular causes of cystic kidney diseases, including those that occur in Alagille Syndrome patients and collecting duct disorders such as Nephrogenic Diabetes Insipidus. The lab has also identified transcription factors and signals that potentially regulate principal versus intercalated cell differentiation.

Primary Research Group

Pediatrics and Rare Diseases

Secondary Research Groups

About the Surendran Lab

Lab Projects and News

Meet the Surendran Team