Roux Lab

Graduate Student Mentor

Primary Research Focus

The nuclear envelope sits at the critical interface between the cell’s nucleus and cytoplasm. Therefore, it should be no surprise that defects in nuclear envelope constituents give rise to a myriad of rare diseases.

In response to barriers in his research on the nuclear envelope, Dr. Kyle Roux established a method called BioID to screen for protein proximity and interactions in living cells, thus overcoming several limitations intrinsic to conventional approaches. Since it is uniquely capable of screening for protein associations in living cells, BioID is rapidly becoming an established method used by the scientific community.

Dr. Roux’s ongoing research program is focused on further development and applications of BioID, and combining BioID with conventional approaches to study the structure and function of the nuclear envelope and its associated diseases.

Defects in a cellular structure termed the nuclear envelope are associated with a myriad of diverse diseases, collectively called nuclear envelopathies. Most of these disorders clinically manifest during the first two decades of life and include muscular dystrophy, cardiomyopathy, lipodystrophy, dystonia, neuropathy, skeletal defects, and progeria.

The nuclear envelope is situated at a critical juncture in the cell, both intimately associated with the genome and responsible for connecting it to the rest of the cell. While it is clear that mutations in genes encoding protein constituents of the nuclear envelope underlie these diseases, the exact mechanisms remain largely unknown. In part, these nuclear envelopathies involve a nuclear envelope structure called the LINC-complex that is responsible for linking the nucleoskeleton to the cytoskeleton.

Primary Research Group

Enabling Technologies

Secondary Research Groups

About the Roux Lab

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