Masuho Lab

Primary Research Focus

The Masuho Lab studies molecular and cellular aspects of G protein-coupled receptor (GPCR) signaling. GPCRs are the largest class of cell surface receptors and are activated by a diverse range of extracellular stimuli, including hormones and neurotransmitters. They play crucial roles in cellular functions, such as chemotaxis and synaptic plasticity, and are involved in virtually all physiological processes.

As a system with much physiological importance, dysregulation in the GPCR signaling system has been implicated in a broad range of human disorders. These receptors are also the primary target of current therapeutic agents. Therefore, a precise understanding of the signaling pathways at the molecular and cellular levels is among the highest priorities of public health research.

This lab aims to interpret the molecular mechanisms and structural basis of how GPCR signaling molecules control broad cellular functions, identify the causes of diseases and apply these findings to medical treatment.

Primary Research Group

Pediatrics and Rare Diseases

Secondary Research Groups

About the Masuho Lab

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