Francis Lab

Graduate Student Mentor
COBRE Project Leader

Primary Research Focus

Through the use of novel physiologically relevant human induced pluripotent stem cell models and transgenic mouse models, Dr. Kevin Francis’ laboratory is focused on defining the biological mechanisms underlying disorders of neurodevelopment using human induced pluripotent stem cells (iPSCs) derived from rare patient populations.

As a doctoral student and postdoctoral fellow, Dr. Francis received extensive training in patch clamp electrophysiology, neurodevelopment, cellular stress, genetics, lipid biology and pluripotent stem cell biology. Using this expertise, our laboratory at Sanford Research has developed induced pluripotent stem cell (iPSC) models of rare patient populations to identify cell specific effects and signaling mediated events resulting from genetic mutations within critical genes regulating lipid metabolism, neuronal cell health and leading to patient pathology (for example, Nat Med, 2016, 22(4):388-96).

Dr. Francis has formed strong collaborations with experts in the fields of neurodevelopment, cell signaling, -omics methodology, and the development of therapeutics to define disease pathogenesis and identify novel therapies for rare diseases.

About the Francis Lab

Lab Projects and News

Meet the Francis Lab Team