Primary Research Focus
Kidneys play a crucial role in maintenance of pH, water, and electrolyte balance in our body. The renal epithelial cells that perform the ion and water reabsorption are diverse in nature. Chandrasekar lab is interested in understanding the role of the actin cytoskeleton and associated myosin motor proteins in regulation of renal epithelial transport pathways and transport related kidney disease. We use a multifaceted approach involving conditional knockout mouse models, cell biological, biochemical methods including advanced microscopy techniques. The lab is also involved in development and application of novel tools and techniques to study membrane remodeling, organelle structure and function in vitro in cell culture and in vivo in mouse and human kidneys.