Primary Research Focus
Evaluation of the host immune response in respiratory viral infection at the systemic and mucosal level. My lab focus on characterizing the immune response and transcriptional profiling during viral infection to better understand the pathogenesis during respiratory viral infection as well as develop a predicting model for disease severity and potentially diagnosis.
We perform detailed immunophenotyping on blood samples and nasal wash sample using flow cytometry with characterization of the adaptive and the innate immune system, including B cells, plasma B cells, plasmablast, T cells (CD4/CD8), natural killer cells, monocytes, neutrophils, and dendritic cells. In addition, cytokines measurement in both compartment. Finally, transcriptional profiling by RNA-sequencing on peripheral blood samples and upper airway samples (NP and/or nasal wash).
In addition, we have ongoing pediatric vaccine clinical evaluating safety and vaccine effectiveness.
About the Lopez Lab
Meet the Lopez Lab
Khaled Ismail, MD
Associate Research Specialist
Khaled Ismail, MD, joined Lopez Lab in 2020. He studies mucosal immune responses during acute viral lower respiratory tract infections (LRTI) caused by respiratory syncytial virus (RSV), influenza, human metapneumovirus (hMPV) or SARS-COV-2 using single-cell sequencing and flow cytometry.
Dr. Ismail earned his medical degree from the Alexandria University School of Medicine in Egypt in 2016. He finished his medical internship at the Alexandria University Hospital in Egypt and the Aachen University Hospital in Germany.