Faustino Lab

Graduate Student Mentor
COBRE Project Leader

Primary Research Focus

Global mortality rates are led by cardiac disease, yet many of its causes are unknown. A long-term interest of the Faustino Lab is the identification and characterization of novel regulators involved in the development and progression of cardiac pathology.

Specifically, we are interested in understanding cell nucleus dynamics that underlie the progression and severity of electrical and muscle disorders of the heart. Greater understanding of these processes will advance the field in innovative directions that support our ultimate goal to improve strategies to address heart disease.

Our work uses several platforms that model cardiac disease processes to help us address our scientific interest.

Spontaneous and induced models of heart failure allow us to study structural and functional changes in the heart in a physiological setting, while a variety of animal and human cell-based platforms allow us to examine mechanistic changes at the subcellular level.

In addition, we use epigenomic, transcriptomic, and proteomic based approaches paired with bioinformatic analyses to understand the molecular networks, or systems biology processes, underlying cardiac pathology.

The immediate objectives of these approaches are designed to help us elucidate non-sarcomeric and non-channelopathy etiologies that account for idiopathic cardiac pathologies, with the ultimate goal of identifying novel targets that can be used to treat heart disease.

About the Faustino Lab

Lab Projects and News

Meet the Faustino Lab Team